Identification of a potential relationship between pigmented villonodular synovitis and atherosclerosis using comprehensive bioinformatics analyses

Key Points

• This research aims to explore the connection between pigmented villonodular synovitis and atherosclerosis using bioinformatics analyses.
• Utilized comprehensive bioinformatics approaches
• Conducted single-cell RNA sequencing (scRNA-seq)
• Analyzed immune cell compositions
• Evaluated the role of CSF2RB in diagnosis and therapy
• Identified CSF2RB as a potential diagnostic and therapeutic target
• Observed increased levels of macrophages and T cells in PVNS
• Disrupted immune cell composition was evident in the analyses