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February 6, 2026European Heart Journal

The correlation between osteoporosis, fracture risk and the risk of adverse cardiovascular events according to the novel SCORE2/SCORE2-OP scale in postmenopausal females

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Authors

AKAnna KawińskaESEwa SewerynekJKJ Krekora

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Overview

Observational study assesses cardiovascular risk and fracture correlation in postmenopausal women, suggesting implications for assessing health risks.

Key Points

  • The aim is to investigate the relationship between osteoporosis, fracture risk, and cardiovascular events using the SCORE2/SCORE2-OP algorithms.
  • Evaluated 103 postmenopausal females with mean age 69 and assessed bone mineral density (BMD) via dual energy X-ray absorptiometry.
  • Divided participants into groups based on BMD: 51 with osteoporosis and 52 matched controls without osteoporosis.
  • Excluded those with heart failure, acute coronary syndromes, or severe valvular disease.
  • Utilized SCORE2/SCORE2-OP to assess cardiovascular risk and the FRAX scale for fracture risks.
  • Found a significant negative correlation between SCORE2-OP and BMD at femoral neck and total hip.
  • Established a significant positive correlation between SCORE2-OP and both major osteoporotic fracture risk and total hip fracture risk.
  • Identified positive correlations between THFR and SCORE2-OP in both osteoporosis and control groups.

Cite This Study

Kawińska et al. (2025) studied this question.

synapsesocial.com/papers/6985852f8f7c464f2300869bhttps://doi.org/10.1093/eurheartj/ehaf784.3999
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study2024 · 12 citations
  2. 2Establishment and Validation of a Predictive Nomogram Model for Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus: A Retrospective Study2025
  3. 3The association between 10-year cardiovascular risk and fracture incidence in postmenopausal women: a prospective analysis from the Women's Health Initiative2026 · 1 citations
  4. 4Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women2017 · 21 citations
  5. 5Bone microarchitecture and fracture risk in rheumatoid arthritis2024 · 1 citations