Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
January 1, 2017Circulation JournalOpen Access

Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women

View Full Paper
Ask AI
Bookmark
Share

Population

414 subjects aged 40-89 years undergoing health screening, mean age 67, 58.2% male, based in Japan.

Design

Cross-sectional, Observers were blind to the purpose of this study for…

Key result

An increased 10-year risk of osteoporotic fracture (FRAX score) was significantly associated with impaired flow-mediated vasodilation (r=-0.16), nitroglycerine-induced vasodilation (r=-0.22), and increased brachial artery intima-media thickness (r=0.12).

Authors

MKMasato KajikawaNONozomu OdaSKShinji Kishimoto

Discussion

Loading...

Member takes

Overview

Higher FRAX may signal subclinical vascular dysfunction; hypothesis-generating and should not change practice without longitudinal data.

Study Design

Type

Cross-Sectional (n=414)

Blinding

Single-blind

Multicenter

No

Structured PICO

P
Population
414 adults aged 40 to 89 years undergoing routine health screening were assessed cross-sectionally to evaluate the association between 10-year osteoporotic fracture risk and vascular function.
O
Outcome
Vascular function assessed by flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID), and vascular structure assessed by brachial artery intima-media thickness (IMT)surrogate

Main Result

Effect estimate: r=-0.16

p-value: p=<0.001

An increased risk of osteoporotic fracture, as evaluated by the FRAX score, is independently associated with subclinical atherosclerosis and vascular dysfunction in both men and women.

Limitations

  • Cross-sectional design precludes establishing a causal relationship between osteoporotic fracture risk and vascular function.
  • FRAX does not take into account some risk factors for osteoporosis such as frequency of bone fracture.
  • Unobserved confounders and cardiovascular risk factors included in FRAX may have affected the relationships.
  • FRAX was calculated without bone mineral density (BMD) measurements.
  • Cross-sectional design cannot establish causal relationship
  • FRAX is designed for use in adults aged ≥40 years
  • Menopausal status is a risk factor for endothelial dysfunction
  • Unobserved confounders may have affected the relationships
  • FRAX was calculated without bone mineral density (BMD)

Cite This Study

Kajikawa et al. (2017) conducted a cross-sectional in General population undergoing health screening (n=414). 10-year risk of major osteoporotic fracture (FRAX score) vs. Lower FRAX score was evaluated on Correlation between FRAX score and flow-mediated vasodilation (FMD) (r=-0.16, p=<0.001). An increased 10-year risk of osteoporotic fracture (FRAX score) was significantly associated with impaired flow-mediated vasodilation (r=-0.16), nitroglycerine-induced vasodilation (r=-0.22), and increased brachial artery intima-media thickness (r=0.12).

synapsesocial.com/papers/6a20902605ff00c089b41c2dhttps://doi.org/10.1253/circj.cj-16-1236
View Full Paper
Ask AI
Bookmark
Share