Two heterodimeric sesquiterpenoids, chlorjaponoids A (1) and B (2), were isolated from the whole plants of Chloranthus japonicus. Their structures, characterized by a unique cage-like tetracyclo8.5.0.02,7.03,13pentadecane scaffold, were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction. Both compounds demonstrated antihepatic fibrosis activity in vitro.
Gan et al. (2026) studied this question.