Identifies chlorjaponoids A and B, compounds showing antihepatic fibrosis activity in vitro, suggesting new therapeutic options.
Two heterodimeric sesquiterpenoids, chlorjaponoids A (1) and B (2), were isolated from the whole plants of Chloranthus japonicus. Their structures, characterized by a unique cage-like tetracyclo[8.5.0.0²,⁷.0³,¹³]pentadecane scaffold, were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction. Both compounds demonstrated antihepatic fibrosis activity in vitro.
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Gan et al. (2026) studied this question.
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