What question did this study set out to answer?

To evaluate the relationship between bisphosphonate use, atypical femoral fractures, and physical activity levels.

February 8, 2026FUKUSHIMA JOURNAL OF MEDICAL SCIENCE0 citationsOpen Access

Preliminary analysis for the ADD-BP study: Atypical femoral fractures and physical activity levels in bisphosphonate users

TYTakeru Yokota TKTakuya Kameda TNTakuya Nikaido

Key Points

To evaluate the relationship between bisphosphonate use, atypical femoral fractures, and physical activity levels.
Comparison of physical activity levels between bisphosphonate users and non-users
Observational study design
Ethical approval from Fukushima Medical University
Bisphosphonate users with atypical femoral fractures reported higher levels of physical activity than non-users
Low physical activity does not appear to increase the risk of atypical femoral fractures in long-term bisphosphonate users
Findings support the safety of extended bisphosphonate therapy for less active individuals

Abstract

BP users with AFF exhibited higher physical activity levels than non-users, suggesting low activity may not elevate AFF risk in long-term BP use. These findings support the safety of extended BP therapy for fragility fracture prevention in less active patients. Future case-control studies are needed to confirm these results. This study was approved by the Fukushima Medical University Ethics Committee (REC2023-176).

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