Cinnamophilin ameliorates testosterone-induced prostatic hyperplasia and fibrosis by regulating 5α-reductase and TGF-β/Smad signaling pathway.

Key Points

• This research aims to examine how cinnamophilin affects testosterone-induced prostatic hyperplasia and fibrosis.
• Evaluated the effect of cinnamophilin on prostate growth in a testosterone-induced model.
• Investigated the role of 5α-reductase and TGF-β/Smad signaling pathways in the process.
• Analyzed changes in epithelial-mesenchymal transition (EMT) and fibrosis levels.
• Cinnamophilin significantly inhibited prostate growth stimulated by testosterone.
• Reduced markers of fibrosis were observed in treated samples.
• Regulation of TGFβ/Smad signaling pathways was confirmed, impacting EMT and fibrosis.