Integrated CMR-Doppler derived EROA showed strong correlation (r=0.91) with PISA-EROA and improved reproducibility (ICC up to 0.96), reclassifying 14% of severe TR patients.
Does an integrated CMR and echocardiography approach accurately quantify tricuspid regurgitation EROA compared to conventional 2DE PISA in patients undergoing tricuspid valve surgery?
Combining CMR-derived regurgitant volume with echocardiographic continuous-wave Doppler provides a reproducible method for quantifying tricuspid regurgitation EROA that may reclassify disease severity compared to single-modality imaging.
Absolute Event Rate: 0% vs 0%
Abstract Background Effective regurgitant orifice area (EROA) is the key parameter to quantify tricuspid regurgitation (TR). However, conventional two-dimensional echocardiography (2DE) proximal isovelocity surface area (PISA) method is limited by geometric assumptions, irregular orifice shapes, and suboptimal inter-observer reproducibility. Cardiac magnetic resonance (CMR) quantifies TR using volumetric method avoids such limits and is more reproducible but cannot directly quantify EROA. Purpose This study aimed to validate the feasibility of a novel integrated approach combining CMR-derived regurgitant volume (RVol) with continuous-wave Doppler (CW)-measured velocity-time integral (VTI) to calculate EROA (EROAintegrated) and compare its performance against conventional PISA-EROA and CMR-derived parameters. Methods A prospective cohort of 30 patients scheduled for isolated or concomitant tricuspid valve surgery underwent preoperative 2DE and CMR on the same day. EROAintegrated was calculated as RVol/VTI, where RVol was derived from the difference between right ventricular (RV) stroke volume (using CMR cine sequences) and RV outflow tract stroke volume (using phase-contrast imaging). PISA-EROA was measured according to guidelines. TR severity was classified using a multi-parametric algorithm. Results Of 30 enrolled patients, 28 were analyzed (2 excluded due to arrhythmia-related phase-contrast acquisition failure). EROAintegrated demonstrated strong linear correlation with PISA-EROA (r = 0.91, P 0.001), though Bland-Altman analysis revealed wide limits of agreement (−61.3 to 75.5 mm²). EROAintegrated also correlated well with CMR RVol (r = 0.91) and logarithmically with regurgitant fraction (RF, r = 0.87). ROC analysis showed comparable AUCs for EROAintegrated and CMR RVol in diagnosing severe TR (P 0.05 for pairwise comparisons). Using a 40 mm² cutoff, EROAintegrated reclassified 14% of patients initially diagnosed as severe TR by PISA-EROA into non-severe categories. Similarly, CMR RVol (45 ml cutoff) reclassified 14% of EROAintegrated-defined severe TR cases. EROAintegrated exhibited better inter- and intra-observer consistency (ICC: 0.94 and 0.96) compared to PISA-EROA (ICC: 0.86 and 0.95). Conclusion The combined CMR-Doppler approach provides a feasible, reproducible method for quantifying TR EROA, correlating with conventional metrics. EROAintegrated reclassifies patients graded with either 2DE or CMR alone. This study highlights the nessesity of multimodal imaging to refine TR evaluation.Agreement with conventional EROA Reclassification of TR severity
Liu et al. (Sat,) reported a other. Integrated CMR-Doppler derived EROA showed strong correlation (r=0.91) with PISA-EROA and improved reproducibility (ICC up to 0.96), reclassifying 14% of severe TR patients.