In ToF patients, right ventricle tissue Doppler systolic velocity strongly correlates with VO2-peak (rho=0.62, p=0.009), and high RV systolic pressure correlates negatively with VO2-peak.
Do echocardiographic variables of right ventricular function correlate with peak oxygen uptake in adult patients with tetralogy of Fallot?
In adult patients with tetralogy of Fallot, right ventricular tissue Doppler systolic velocity (TDIs') and right ventricular systolic pressure (RVSP) correlate significantly with peak oxygen uptake, serving as potential non-invasive prognostic markers for exercise capacity.
Absolute Event Rate: 0% vs 0%
Abstract Background Adult patients with tetralogy of Fallot (ToF) have been shown to have diminished exercise capacity and reduced peak oxygen uptake (VO2-peak) compared to healthy controls, with impaired right ventricular function being a contributing factor. However, echocardiographic assessment of the right ventricle is challenging, and there is limited data on the accuracy and prognostic value of these echocardiographic variables. Purpose To identify echocardiographic variables of right heart function that correlate with exercise capacity, as assessed by VO2-peak, among patients with ToF. Methods As part of the ongoing multicentre Swedish study on congenital heart disease, IMPROVE-ACHD, initiated in 2022, the first 24 patients with ToF have been included. The participants underwent a cardiopulmonary exercise test on a cycle ergometer, and within the framework of their clinical follow-up, variables from their latest echocardiography were collected. Data were found to not be normally distributed. The participants were divided into two groups based on VO2-peak greater than or less than the median (23ml/min/kg), and a Mann-Whitney U-test was performed for comparison. Spearman’s correlation and multiple regression models, adjusted for age and sex, were used to assess the association between echocardiographic variables and VO2-peak/kg. Results Demographic characteristics, echocardiography and exercise test results are shown in Table 1. Of the tested echocardiographic variables, tissue Doppler systolic velocity of the lateral wall of right ventricle (TDIs´) showed the strongest correlation with VO2-peak/kg (Spearman’s rho = 0.62, p = 0.009, and standardized β = 0.599, p = 0.014). Right ventricular systolic pressure (RVSP) showed a negative correlation with VO2-peak/kg (Spearman’s rho = -0.51, p = 0.051, and standardized β = -0.585, p = 0.032) see Table 2. Conclusions In patients with ToF, low TDIs´ and high RVSP values indicate a lower VO2-peak and, therefore, they may indicate a worse prognosis. The predictive value of these measures needs further exploration in larger cohorts.
Galos et al. (Sat,) reported a other. In ToF patients, right ventricle tissue Doppler systolic velocity strongly correlates with VO2-peak (rho=0.62, p=0.009), and high RV systolic pressure correlates negatively with VO2-peak.