Overexpression of Rtl1 via synonymous mutation silencing miRNA target site drives skeletal muscle hypertrophy and inflammation in mice

Key Points

• This research investigates how Rtl1 overexpression affects skeletal muscle hypertrophy and inflammation.
• Utilized murine models to assess Rtl1 expression levels.
• Examined changes in muscle size and inflammatory markers.
• Implemented techniques to silence miRNA target site via synonymous mutation.
• Rtl1 overexpression is linked to increased muscle hypertrophy.
• Elevated inflammation markers were detected in overexpressed Rtl1 muscle tissues.