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February 9, 2026Brain Research Bulletin0 citationsOpen Access

Orexin dual receptor antagonist attenuates neurological deficits possibly via PI3K/Akt/mTOR pathway activation in sleep-deprived stroke rats

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LWLili WangXXXinli XiongBWBaofeng Wang

Key Points

  • The aim is to investigate whether orexin dual receptor antagonists can reduce neurological deficits in sleep-deprived stroke rats and explore associated signaling pathways.
  • Administered almorexant to sleep-deprived stroke rats
  • Assessed neurological deficits through behavioral tests
  • Evaluated changes in PI3K/Akt/mTOR signaling pathways
  • Almorexant treatment led to reduced neurological deficits in stroke rats
  • Activation of the PI3K/Akt/mTOR pathway was observed
  • Potential role in managing post-stroke insomnia was suggested

Abstract

Almorexant was associated with attenuation of SD-exacerbated ischemic brain injury in rats, accompanied by alterations in PI3K/Akt/mTOR signaling, suggesting DORAs may have potential relevance for the management of post-stroke insomnia.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/698978dff0ec2af6756e7199https://doi.org/10.1016/j.brainresbull.2026.111762
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