Expression of Survivin and HER-2 as Independent Predictive Factors for Treatment Response in Locally Advanced Breast Cancer: A Prospective Cohort Study

Key Points

• The study aims to evaluate the role of survivin and HER-2 as independent predictors of treatment response in locally advanced breast cancer (LABC).
• Conducted as a prospective cohort study
• Evaluated survivin and HER-2 expression in patients with LABC
• Assessed response to neoadjuvant chemotherapy (NACT)
• Survivin and HER-2 expression are significantly associated with poor response to NACT
• Both biomarkers serve as independent predictors of treatment outcomes