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February 11, 20260 citations

LOX-1 gene knockout improves metabolic dysfunction-associated steatohepatitis in mice.

RHRuihua HuangYYYongyu YangSZShuhan Zhou

Key Points

  • This research aims to investigate the effects of LOX-1 gene knockout on metabolic dysfunction-related steatohepatitis in mice.
  • Conducted experiments on mice subjected to a Western diet
  • Performed gene knockout of LOX-1
  • Assessed metabolic parameters and steatohepatitis progression
  • LOX-1 knockout improved metabolic dysfunction
  • Decreased severity of steatohepatitis observed in treated mice
  • Indicates potential for LOX-1 as a therapeutic target

Abstract

LOX-1 gene knockout ameliorates Western diet-induced MASH in mice and may serve as a potential therapeutic target.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/698c1bef267fb587c655dff3https://doi.org/10.11817/j.issn.1672-7347.2025.250194
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