What question did this study set out to answer?

The aim is to develop a predictive model for nurses' support regarding the decriminalization of psychedelics.

February 11, 2026Psychedelic Medicine1 citations

Predicting Nurses’ Views on Decriminalization of Psychedelics

CPCarolyn M. PortaRegions Hospital CWCheng-Chang WuColorado School of Public Health AGAnna GraefeUniversity of Minnesota

Key Points

The aim is to develop a predictive model for nurses' support regarding the decriminalization of psychedelics.
Secondary analysis of e-survey data from 1092 registered nurses in Minnesota.
Utilized multinomial logistic regression with backward selection for model development.
Applied the Akaike information criterion for model optimization.
Assessed model performance using multiclass area under the curve (AUC).
Identified key predictors including age, gender identity, spiritual orientation, and awareness of psychedelic laws.
The final model achieved a multiclass AUC of 0.870, indicating strong predictive power.
Outstanding discrimination was noted between supporters and opponents with an AUC of 0.973.

Abstract

Background: Despite being the largest sector of the health care workforce with potential to support advancing psychedelics in health care, nurses and their views toward psychedelics and changing legal restrictions remain mostly unknown. Aims: To identify an optimal predictive model for nurses’ support (or not) of decriminalization of psychedelics. Methods: Secondary analysis of e-survey data from 1092 registered nurses and advanced practice registered nurses invited randomly from the Minnesota Board of Nursing registry. To develop an optimal predictive model, multinomial logistic regression with backward selection using the Akaike information criterion (AIC) was applied to the training set. The final model was fitted to the validation set for effect estimation, with performance assessed using multiclass area under the curve (AUC). Results: Backward selection using AIC identified several key predictors of support for decriminalization of psychedelics in Minnesota: age, gender identity, specific spiritual orientation, awareness of Colorado’s psychedelic decriminalization, and scores from the Attitudes and Perceptions Questionnaire legal and effects subscales. The final model demonstrated excellent discriminative ability with a multiclass AUC of 0.870 (95% confidence interval CI: 0.847–0.898). Pairwise comparisons revealed outstanding discrimination between supporters and opponents of decriminalization (AUC = 0.973, 95% CI: 0.952–0.987). Conclusion: Age (younger/older), (awareness/lack of awareness) of Colorado’s decriminalization laws, and attitudes (concerns/lack of concerns) toward effects and legal status of psychedelics predicted a nurse’s (more/less positive) attitude toward psychedelics. This model offers an informative starting point for understanding nurses’ and, by proxy, the communities in which they live and work and provides initial direction toward tailoring curricular and professional development resources on psychedelics for nurses across the United States.

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