Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial

Key Points

• This research aims to evaluate the effectiveness of a 1-month tuberculosis preventive therapy in patients with advanced HIV and cryptococcal meningitis.
• Non-inferiority, randomized controlled trial design
• Inpatients with advanced HIV disease and cryptococcal meningitis
• Intervention using isoniazid and rifapentine for 1 month
• The treatment was found to be equally effective compared to standard care
• Participants showed significant improvement in tuberculosis preventive measures
• No major safety issues were reported with the combined therapy