Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial

Key Points

This research aims to evaluate the effectiveness of a 1-month tuberculosis preventive therapy in patients with advanced HIV and cryptococcal meningitis.
Non-inferiority, randomized controlled trial design
Inpatients with advanced HIV disease and cryptococcal meningitis
Intervention using isoniazid and rifapentine for 1 month
The treatment was found to be equally effective compared to standard care
Participants showed significant improvement in tuberculosis preventive measures
No major safety issues were reported with the combined therapy

Non-inferiority trial evaluates tuberculosis treatment in advanced HIV patients with cryptococcal meningitis, indicating potential benefits.

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Ellis et al. (2026) studied this question.

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