Angiotensin II infusion induced abdominal aortic aneurysm in apoE -/- mice with 324 circRNAs differentially expressed compared to controls, including 90 upregulated and 234 downregulated circRNAs (p < 0.05).
Does angiotensin II infusion alter the expression profile of circular RNAs in the abdominal aorta of apoE-/- mice?
Significant differential expression of circRNAs in Ang II-induced AAA mice suggests that the circRNA-miRNA-mRNA axis may serve as a potential molecular regulatory mechanism for abdominal aortic aneurysms.
Effect estimate: 90 circRNAs upregulated and 234 circRNAs downregulated (fold change ≥1.5, p < 0.05)
Absolute Event Rate: 324% vs 0%
p-value: p=<0.05
The differential expression of various circRNAs identified in AAA suggests that the circRNA-miRNA-mRNA axis may serve as a potential molecular regulatory mechanism for AAA.
Lou et al. (2026) studied Male apolipoprotein E-deficient (apoE -/-) mice aged 12 weeks with angiotensin II-induced abdominal aortic aneurysm (n=30). Angiotensin II infusion vs. saline infusion was evaluated on Differential expression of circular RNAs in abdominal aortic tissue (90 circRNAs upregulated and 234 circRNAs downregulated (fold change ≥1.5, p < 0.05), p=<0.05). Angiotensin II infusion induced abdominal aortic aneurysm in apoE -/- mice with 324 circRNAs differentially expressed compared to controls, including 90 upregulated and 234 downregulated circRNAs (p < 0.05).