The dopamine D3 receptor regulates dopamine-induced activation and glycolytic metabolism of synovial fibroblasts in rheumatoid arthritis.

Key Points

• Investigate how the dopamine D3 receptor influences activation and glycolytic processes in synovial fibroblasts in rheumatoid arthritis.
• Examine dopamine-induced activation of RASFs
• Assess glycolytic metabolism in the presence of D3R
• Analyze the role of PKA activity in these processes
• D3R downregulates dopamine-induced activation of RASFs
• Inhibition of PKA activity leads to reduced glycolysis
• Manipulating the D3R pathway may offer a new therapeutic strategy