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February 12, 2026Applied Organometallic Chemistry2 citations

Iridium‐Catalyzed C–H Silylation of Indoles With Hydrosilanes in Aqueous Media

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JZJingyi ZhanXTXinni TangXZXuyao Zhong

Key Points

  • The research aims to develop a process for C–H silylation of indoles using iridium catalysis in water.
  • Utilized iridium as a catalyst for the reaction.
  • Carried out the silylation in aqueous media to leverage sustainability.
  • Directed the reaction to introduce silyl groups specifically at the C2 position of indoles.
  • Successfully demonstrated the C–H silylation of a variety of indoles.
  • Establishes the feasibility of reactions in aqueous media as a sustainable solvent.
  • Represents the first transition metal-catalyzed C–H silylation performed in water.

Abstract

ABSTRACT Herein, we report that directed C–H silylation of indoles and a pyrrole derivative with hydrosilanes in aqueous media under air was achieved under iridium catalysis. This reaction enables the introduction of a silyl group at the C2 position of a wide range of indoles. The protocol represents the first example of a transition metal‐catalyzed C–H silylation in aqueous media as a sustainable solvent for C–H functionalization of indoles.

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Cite This Study

Zhan et al. (2026) studied this question.

synapsesocial.com/papers/698d6ebb5be6419ac0d54750https://doi.org/10.1002/aoc.70536
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