Directed C–H silylation enhances indole functionalization in aqueous media, suggesting a sustainable approach.
Herein, we report that directed C–H silylation of indoles and a pyrrole derivative with hydrosilanes in aqueous media under air was achieved under iridium catalysis. This reaction enables the introduction of a silyl group at the C2 position of a wide range of indoles. The protocol represents the first example of a transition metal‐catalyzed C–H silylation in aqueous media as a sustainable solvent for C–H functionalization of indoles.
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Zhan et al. (2026) studied this question.
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