Iridium‐Catalyzed C–H Silylation of Indoles With Hydrosilanes in Aqueous Media

Key Points

• The research aims to develop a process for C–H silylation of indoles using iridium catalysis in water.
• Utilized iridium as a catalyst for the reaction.
• Carried out the silylation in aqueous media to leverage sustainability.
• Directed the reaction to introduce silyl groups specifically at the C2 position of indoles.
• Successfully demonstrated the C–H silylation of a variety of indoles.
• Establishes the feasibility of reactions in aqueous media as a sustainable solvent.
• Represents the first transition metal-catalyzed C–H silylation performed in water.