What question did this study set out to answer?

The aim is to analyze the relationship between strain in the optic nerve head and functional loss in glaucoma.

February 13, 2026Investigative Ophthalmology & Visual Science1 citationsOpen Access

AI to Identify Strain-Sensitive Regions of the Optic Nerve Head Linked to Functional Loss in Glaucoma

TCThanadet Chuangsuwanich MNMonisha E. Nongpiur FBFabian A. Braeu

Key Points

The aim is to analyze the relationship between strain in the optic nerve head and functional loss in glaucoma.
Utilized AI algorithms for classification of glaucomatous visual field loss patterns.
Focus on neuroretinal rim strain and its impact on axonal injury.
Assessment of strain in the optic nerve head as a predictive measure for functional outcomes.
Identified the neuroretinal rim as the most critical region for classification of functional loss.
Highlighted that rim strain significantly influences axonal injury and functional decline in glaucoma.

Abstract

ONH strain enhances classification of glaucomatous VF loss patterns. The neuroretinal rim, rather than the LC, was most critical, suggesting rim strain may play a dominant role in axonal injury and functional loss.

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