Tunable CTPhos and Chloride Enabled Direct Asymmetric Reductive Amination for the Synthesis of Chial Hydroxylamines

Key Points

• To develop a novel method for synthesizing chiral hydroxylamines using direct asymmetric reductive amination.
• Utilized CTPhos and chloride for reaction.
• Conducted experiments to optimize conditions for asymmetric induction.
• Analyzed the efficiency of producing chiral hydroxylamines.
• Achieved high yields of chiral hydroxylamines.
• Demonstrated positional control over chirality in products.
• Established new reaction pathway for synthesis of bioactive molecules.