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February 14, 2026Systematic ReviewsOpen Access

Effects of exercise training among adults with multiple sclerosis: protocol for a systematic review that informs an updated prescriptive guideline

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Authors

LDLouise DeclerckKGKathleen Martin GinisACAmy Cheung

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Overview

This systematic review evaluates exercise training outcomes in adults with multiple sclerosis, suggesting an updated guideline for practice.

Key Points

  • To assess the necessary type and dose of exercise training for improving health outcomes in adults with multiple sclerosis.
  • Conducting a systematic review following PRISMA-P guidelines.
  • Including randomized controlled trials of chronic exercise interventions for MS.
  • Excluding studies focused on other neurological conditions or qualitative data.
  • Performing a comprehensive search across eight electronic databases.
  • Assessing methodological quality and risk of bias using TESTEX and RoB 2 tools.
  • Identifying the types of exercise that improve fitness and health biomarkers in individuals with MS.
  • Determining effects on physical and cognitive function, quality of life, and daily activity participation.

Cite This Study

Declerck et al. (2026) studied this question.

synapsesocial.com/papers/699010382ccff479cfe56bcehttps://doi.org/10.1186/s13643-026-03095-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional exercise training in persons with multiple sclerosis: a systematic review2025 · 1 citations
  2. 2Study protocol: effects of exercise booster sessions on preservation of exercise-induced adaptations in persons with multiple sclerosis, a multicentre randomised controlled trial—the MS BOOSTER trial2024 · 3 citations
  3. 3[Effectiveness of Resistance Training on Multiple Sclerosis-Related Fatigue: A Systematic Review].2025
  4. 4Prescribing Resistance Training in Multiple Sclerosis2026
  5. 5Patient and clinician perspectives of online-delivered exercise programmes for chronic musculoskeletal conditions: protocol for a mixed-methods systematic review.2024