The research aims to investigate the metabolic abnormalities in multiple system atrophy and their relation to brain network patterns.
Analyzed brain imaging data.
Identified large-scale brain networks involved in metabolic abnormalities.
Decomposed metabolic patterns corresponding to different disease mechanisms.
Five large-scale brain networks were identified.
The findings provide a comprehensive understanding of MSA mechanisms.
Patterns suggest variability in metabolic function across patients.
Abstract
This study demonstrated that the metabolic abnormalities in MSA can be decomposed into 5 large-scale brain networks, providing a comprehensive understanding of the disease's heterogeneous mechanisms.