Biological mechanisms underlying the inflammatory radicular cyst formation-focus on epithelial proliferation: a systematic review of experimental cell and tissue models

Key Points

• The research aims to explore the biological mechanisms behind inflammatory radicular cyst development, particularly focusing on epithelial proliferation.
• Conducted a systematic review of experimental cell and tissue models related to inflammatory radicular cysts.
• Analyzed the role of pro-inflammatory mediators in inducing epithelial proliferation.
• Assessed the transition from homeostatic to pathological signaling in chronic periapical inflammation.
• Identified key pro-inflammatory mediators involved in the cyst formation process.
• Showed that epithelial proliferation plays a significant role in the transition to pathological states.
• Highlighted the failure of regulatory checkpoints during chronic inflammation as a contributing factor.