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February 14, 2026Journal of NeuroendocrinologyOpen Access

Relative and normalized iodine concentrations derived from photon counting computed tomography and their correlation with tumor grade and Ki67 in pancreatic neuroendocrine neoplasia: A pilot study

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Authors

MSMarwin‐Jonathan SähnSWSimon WaltermannJOJonas Ottemöller

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Overview

Pilot study demonstrates iodine concentration correlates with tumor grade and Ki67 in pancreatic neuroendocrine neoplasia, suggesting its role as a biomarker.

Key Points

  • This study aims to assess the relationship between iodine concentrations from photon counting computed tomography and tumor characteristics in pancreatic neuroendocrine neoplasms.
  • Analyzed iodine concentration during the portal venous phase
  • Compared iodine concentration against histopathological tumor grade and Ki67
  • Used Spearman's rank correlation for correlation analysis
  • Conducted Mann–Whitney U test for mean concentration comparisons
  • Included eighteen cases of pancreatic neuroendocrine neoplasms
  • Relative iodine concentration correlates strongly with tumor grade (ρ = 0.54, p = 0.02) and Ki67 (ρ = 0.53, p = 0.02)
  • High-grade tumors exhibited higher mean relative iodine concentration (p = 0.02)
  • Normalized iodine concentration showed weak correlations with tumor grade (ρ = 0.33, p = 0.18) and Ki67 (ρ = 0.30, p = 0.22)
  • Mean normalized iodine concentration did not differ significantly between low-grade and high-grade tumors

Cite This Study

Sähn et al. (2026) studied this question.

synapsesocial.com/papers/699011522ccff479cfe57d39https://doi.org/10.1111/jne.70137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Photon Counting Computed Tomography in Rectal Cancer: Associations Between Iodine Concentration, Histopathology and Treatment Response: A Pilot Study.2024 · 7 citations
  2. 2Photon counting computed tomography in head and neck squamous cell carcinoma: iodine concentration and histopathological features2026
  3. 3Clinical Implications of Ki‐67 Index, Grade and Hormonal Changes in Pancreatic Neuroendocrine Tumors: Insights Into Tumor Heterogeneity Based on Primary and Secondary Lesions2025
  4. 4Computed tomography features in prediction of histological differentiation of pancreatic neuroendocrine neoplasms – a single-centre retrospective cohort stud2024
  5. 5The role of CT and MRI in assessing the degree of malignancy of neuroendocrine tumors of the pancreas2025