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February 14, 2026Journal of NeuroendocrinologyOpen Access

Relative and normalized iodine concentrations derived from photon counting computed tomography and their correlation with tumor grade and Ki67 in pancreatic neuroendocrine neoplasia: A pilot study

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Authors

MSMarwin‐Jonathan SähnJohannes Wesling Klinikum MindenSWSimon WaltermannJohannes Wesling Klinikum MindenJOJonas OttemöllerJohannes Wesling Klinikum Minden

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Implication

Pilot study demonstrates iodine concentration correlates with tumor grade and Ki67 in pancreatic neuroendocrine neoplasia, suggesting its role as a biomarker.

Key Points

  • This study aims to assess the relationship between iodine concentrations from photon counting computed tomography and tumor characteristics in pancreatic neuroendocrine neoplasms.
  • Analyzed iodine concentration during the portal venous phase
  • Compared iodine concentration against histopathological tumor grade and Ki67
  • Used Spearman's rank correlation for correlation analysis
  • Conducted Mann–Whitney U test for mean concentration comparisons
  • Included eighteen cases of pancreatic neuroendocrine neoplasms
  • Relative iodine concentration correlates strongly with tumor grade (ρ = 0.54, p = 0.02) and Ki67 (ρ = 0.53, p = 0.02)
  • High-grade tumors exhibited higher mean relative iodine concentration (p = 0.02)
  • Normalized iodine concentration showed weak correlations with tumor grade (ρ = 0.33, p = 0.18) and Ki67 (ρ = 0.30, p = 0.22)
  • Mean normalized iodine concentration did not differ significantly between low-grade and high-grade tumors

Cite This Study

Sähn et al. (2026) studied this question.

synapsesocial.com/papers/699011522ccff479cfe57d39https://doi.org/10.1111/jne.70137
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