Abstract OBJECTIVES The fissure last (FL) technique described in 1998 has the goal of minimising postoperative airleak leaving the stapling of the fissure as the last step. The aim of this study was the reduction in airleak may be already evident 48 hours after surgery. Materials & Methods The hypothesis of the study was that the routine of adopting FL technique during lung resection for NSCLC active may reduce the number of patients presenting an airleak 48 hours after surgery assessed by a digital device. The study was designed as a prospective phase III single-centre 1:1 randomized trial which compared FL technique with standard fissure first (FF) technique. Sample size was calculated assuming a 50% reduction of airleak at 48 hours in the FL group, and it was set at 150 cases according to previously published evidence. RESULTS Regarding the main end-point, airleaks on POD2 were 5% lower in the FL group as compared to the FF group (50% vs 55%, p 0.51) and that difference was maintained on POD 5 (26% vs 32%, p 0.42). In the subgroup of patients in which a higher rate of airleak was expected (Walker 3 and 4, n = 33), the adoption of FL technique did not show a significant benefit in terms of prolonged airleak (PAL), chest drain duration and hospital stay. CONCLUSIONS Results from this study suggest that FL strategy does not confer any benefit in terms of PAL, even in the context of incomplete fissure.
Vaisitti et al. (Tue,) studied this question.