What question did this study set out to answer?

This research aims to explore the current developments and challenges in diagnosing and classifying autoimmune optic neuritis.

February 16, 2026Expert Review of Neurotherapeutics0 citations

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An update on the developments and challenges with the diagnosis and classification of autoimmune optic neuritis

MDMurat DelikayaHumboldt-Universität zu Berlin RHRoua HamdiHumboldt-Universität zu Berlin CBCharlotte BereuterHumboldt-Universität zu Berlin

Key Points

This research aims to explore the current developments and challenges in diagnosing and classifying autoimmune optic neuritis.
Review of diagnostic pathways for autoimmune optic neuritis
Assessment of biomarker utilization including serum glial fibrillary acidic protein
Evaluation of visual evoked potentials in clinical practice
Identification of key biomarkers improving diagnosis of autoimmune optic neuritis
Enhanced diagnostic classification through visual evoked potentials
Standardized pathways suggested for better clinical outcomes

Abstract

Real-world improvements will depend on standardized diagnostic pathways integrating orbital magnetic resonance imaging (MRI), high-quality antibody assays, OCT, and visual evoked potentials (VEP). Fluid biomarkers such as serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP), together with AI-supported analytics, may refine risk estimates, especially in seronegative cases.

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Delikaya et al. (Fri,) studied this question.

synapsesocial.com/papers/69926503eb1f82dc367a0d3d https://doi.org/https://doi.org/10.1080/14737175.2026.2632795

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