Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 16, 2026Journal of NeurologyOpen Access

Oculomotor abnormalities in patients with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) reflect midline cerebellar impairment

View Full Paper
Ask AI
Bookmark
Share

Authors

RSRenana StormBLBente LübbersMBMax Borsche

Discussion

Loading...

Member takes

Overview

Observational study shows smooth pursuit impairment in patients with CANVAS, indicating midline cerebellar dysfunction.

Key Points

  • Examine oculomotor abnormalities in patients with CANVAS related to cerebellar impairment.
  • Compared eye movements of 15 CANVAS patients and 14 healthy subjects
  • Used high-resolution video-based eye tracker for measurements
  • Related cognitive impairment scores to oculomotor performance
  • 70% of patients showed small amplitude gaze-holding deficits
  • 60% had downbeat nystagmus; 13% had upbeat nystagmus
  • Prolonged latency of smooth pursuit acceleration was noted
  • MoCA scores were lower in patients, correlating with latency

Cite This Study

Storm et al. (2026) studied this question.

synapsesocial.com/papers/69926552eb1f82dc367a1425https://doi.org/10.1007/s00415-026-13678-4
View Full Paper
Ask AI
Bookmark
Share