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February 16, 2026Journal of NeurologyOpen Access

Oculomotor abnormalities in patients with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) reflect midline cerebellar impairment

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Authors

RSRenana StormUniversity Hospital Schleswig-HolsteinBLBente LübbersUniversity of LübeckMBMax BorscheLübeck Academy of Music

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Implication

Observational study shows smooth pursuit impairment in patients with CANVAS, indicating midline cerebellar dysfunction.

Key Points

  • Examine oculomotor abnormalities in patients with CANVAS related to cerebellar impairment.
  • Compared eye movements of 15 CANVAS patients and 14 healthy subjects
  • Used high-resolution video-based eye tracker for measurements
  • Related cognitive impairment scores to oculomotor performance
  • 70% of patients showed small amplitude gaze-holding deficits
  • 60% had downbeat nystagmus; 13% had upbeat nystagmus
  • Prolonged latency of smooth pursuit acceleration was noted
  • MoCA scores were lower in patients, correlating with latency

Cite This Study

Storm et al. (2026) studied this question.

synapsesocial.com/papers/69926552eb1f82dc367a1425https://doi.org/10.1007/s00415-026-13678-4
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Also Consider

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  1. 1Video‐Oculography as a Key Diagnostic Tool for SCA27B : A Real‐Life Experience2025 · 3 citations
  2. 2Cognitive Impairment Is Part of the Phenotype of Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome ( CANVAS)2024 · 21 citations
  3. 3Best Oculomotor Endpoints for Clinical Trials in Hereditary Ataxias: A Systematic Review and Consensus by the Ataxia Global Initiative Working Group on Digital‑Motor Biomarkers2025 · 2 citations
  4. 4Distinctive visual tasks for characterizing mild cognitive impairment and dementia using oculomotor behavior2023 · 19 citations
  5. 5Head impulse testing in bilateral vestibulopathy in patients with genetically defined CANVAS2022 · 10 citations