A new atom-transfer radical cyclization (ATRC) mediated by photocatalytically-generated aminyl radicals that do not have an α-C-H bond

Key Points

• The aim is to develop a new method for synthesizing sp3-rich bicyclic iodoacetals using aminyl radicals generated via photocatalysis.
• Utilized catalytic eosin (EY.Na2) as a photocatalyst
• Applied a simple procedure to synthesize compounds
• Combined enol ethers with Boc-protected enamines
• Successfully synthesized sp3-rich bicyclic O,O- and N,O-iodoacetals
• Demonstrated efficiency of the photocatalytic method
• Highlighted the elimination of α-C-H bonds in the process