What does this research mean for the field?

The subgingival microbiota of HCC patients with periodontitis differs significantly from that of periodontitis patients without HCC, providing evidence for the 'oral-liver axis' mechanism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the differences in the subgingival microbial community between HCC patients with periodontitis and periodontitis-only patients.

February 19, 2026European journal of medical research0 citationsOpen Access

Subgingival microbial community structure in HCC patients with periodontitis: 16S rRNA sequencing, functional prediction, and phenotypic profiling

HHHai HeState Ethnic Affairs Commission JZJingli ZhuLanzhou University Second Hospital QSQisheng ShenState Ethnic Affairs Commission

Key Points

To investigate the differences in the subgingival microbial community between HCC patients with periodontitis and periodontitis-only patients.
Used 16S rRNA sequencing to analyze subgingival microbiota
Compared microbial diversity and structure between HCC-PD and PD patients
Performed functional prediction and phenotypic profiling of microbial communities
Significant differences in microbial diversity observed between HCC-PD and PD patients
Distinct structures and relative abundances of dominant bacteria identified
Evidence supports the 'oral-liver axis' mechanism for disease risk assessment

Abstract

The subgingival microbiota of HCC-PD patients differs significantly from that of PD patients in terms of diversity, structure, relative abundance of dominant bacteria, and function, providing microbiological evidence for the 'oral-liver axis' mechanism and offering reference value for disease risk assessment and intervention.

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