Despite the vast number of reports on benzimidazoles, 1,2-substituted N-amido benzimidazoles remain an underrepresented and scarcely accessible compound class with promising pharmacological relevance. We present a safe, reliable electrochemical protocol that provides easy access to those structures. The reaction exhibits broad functional group tolerance and affords the target compounds in ≤89% yields.
Doellerer et al. (Mon,) studied this question.