Background: The effectiveness of conventional chemotherapy in treating metastatic triple-negative breast cancer (TNBC) is unsatisfactory. Apatinib, a small-molecule tyrosine kinase vascular inhibitor (TKI), is a multi-targeted anti-tumor angiogenesis agent that promotes apoptosis to inhibit tumors. Summary: Apatinib, when combined with chemotherapy, has demonstrated efficacy in treating advanced TNBC. Additionally, immune checkpoint inhibitors (ICIs) have emerged as a promising therapeutic option for metastatic TNBC; however, their efficacy still requires further improvement. One potential strategy to enhance the efficacy of ICIs in metastatic TNBC is through their combination with chemotherapy and anti-angiogenic agents. The combination of apatinib, chemotherapy, and ICIs has demonstrated favorable efficacy, with improved progression-free survival (PFS) compared with the conventional chemotherapy for advanced TNBC. This warrants further exploration of its clinical value. This triple therapy exhibits synergistic effects rather than representing a simple combination of agents. Apatinib can reverse chemoresistance and enhance the efficacy of programmed cell death protein 1 (PD-1) inhibitor therapy. Combining chemotherapeutic agents with ICIs is complementary, and apatinib, combined with chemotherapy, can modify the tumor microenvironment to improve the effectiveness of ICIs. Key Messages: This review examines the role of apatinib in treating TNBC and explores its potential mechanisms when combined with chemotherapeutic agents and ICIs for advanced TNBC in the era of immunotherapy.
Huang et al. (Tue,) studied this question.