What question did this study set out to answer?

To investigate the scope and selectivity of Negishi coupling reactions involving aryl iodides in deep eutectic solvents.

February 19, 2026Catalysis Science & Technology0 citationsOpen Access

Exploring pre-catalyst scope and selectivity in Negishi coupling of aryl iodides in deep eutectic solvents

LMLuis Mauricio Murillo-HerreraUniversity of York SFSpencer FrederickUniversity of York SHScott A HicksUniversity of York

Key Points

To investigate the scope and selectivity of Negishi coupling reactions involving aryl iodides in deep eutectic solvents.
Utilized deep eutectic solvents for the coupling reaction.
Applied aryl iodides with various alkyl or arylzinc reagents.
Analyzed the reaction outcomes to determine selectivity and efficiency.
Demonstrated enhanced selectivity for specific products in deep eutectic solvents.
Reactions showed potential for broader application with different aryl iodides.
Highlighting the efficiency of zinc reagents in comparison to traditional methods.

Abstract

Negishi coupling is a valuable synthetic protocol for the formation of C-C bonds. However, the use of highly reactive alkyl-or arylzinc reagents in these reactions usually requires them to be...

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