What question did this study set out to answer?

The research aims to evaluate the long-term effects of intravitreal anti-VEGF therapy on diabetic macular edema (DME) in Türkiye.

February 21, 2026Turkish Journal of Ophthalmology2 citationsOpen Access

Intravitreal Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema in Türkiye: 48-Month Data, BOSPHORUS-DME Study Group Report No. 1

EÖEce ÖzalIstanbul Metropolitan Municipality AÖAbdullah Özkaya MAMurat ArıcıSağlık Bilimleri Üniversitesi

Key Points

The research aims to evaluate the long-term effects of intravitreal anti-VEGF therapy on diabetic macular edema (DME) in Türkiye.
Conducted a real-world study over 48 months in Türkiye
Monitored visual and anatomical changes in DME patients
Assessed injection frequency and treatment adherence
Observed sustained visual and anatomical gains after 48 months
Higher injection frequency correlated with better outcomes
Findings support early and continuous therapy for DME management

Abstract

This is the largest and longest real-world study on DME treatment conducted in Türkiye. It demonstrates that visual and anatomical gains can be sustained over a 48-month period. While the overall trend aligns with previous real-world studies, the higher injection frequency in our cohort appears to have contributed to more favorable outcomes. These findings underscore the importance of early intensive therapy and sustained treatment adherence in the real-world management of DME.

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Cite This Study

Özal et al. (Wed,) studied this question.

synapsesocial.com/papers/69994bdd873532290d01fe0a https://doi.org/https://doi.org/10.4274/tjo.galenos.2026.67863

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