Sickle cell nephropathy (SCN) is one of the complications of sickle cell disease (SCD). It is a chronic and progressive disease that can lead to end-stage kidney disease (ESKD). Anemia is a common complication in SCD and can exacerbate the symptoms of SCN. Anemia in SCN can be due to increased red cell destruction, reduced red cell production, and various non-disease-associated causes. The prolonged anemia in SCN can lead to various complications, which include rapid progression to ESKD, reduced quality of life (QoL), and increased risk of vaso-occlusive complications (VOC). There are many challenges faced by treating nephrologists while managing anemia in SCN, which have been discussed in this review along with possible solutions.
Sotomiwa et al. (Thu,) studied this question.