Abstract Aims Triglyceride‐derived metabolic parameters have been proposed as indirect measures of insulin resistance and also as predictors of worse prognosis, mainly in Asian populations. However, their value as risk predictors of micro‐ and macrovascular complications in non‐Asian individuals with type 2 diabetes is uncertain. Methods Triglyceride‐derived parameters, the atherogenic index of plasma (AIP, the triglyceride/HDL‐cholesterol ratio), the triglyceride‐glucose index (TyG, the triglyceride‐fasting glucose product) and the TyG*BMI were calculated at baseline and during the 1st year of follow‐up in a prospective cohort of 667 individuals with type 2 diabetes. Multivariable Cox analyses assessed the associations between triglyceride‐derived parameters (as continuous and categorical tertile variables) and cardiovascular (total and major cardiovascular events) and microvascular (renal, retinopathy and peripheral neuropathy events) outcomes and mortality. Results Over a median 10.6 years of follow‐up, there were 212 total cardiovascular events (172 major ones), 263 all‐cause deaths and 124 new microalbuminuria developments, 98 advanced renal function deteriorations, 154 retinopathy and 173 peripheral neuropathy development/progression events. None of the triglyceride‐derived metabolic parameters, either analysed as continuous or categorical variables, were associated with significantly higher risks for any of the adverse outcomes. The best predictive performance was the 1st year TyG for retinopathy development/progression (HR: 1.24; 95%CI: 1.01–1.53, for increments of 1‐SD), which attenuated to non‐significant (HR: 1.16; 95%CI: 0.92–1.45) after further adjustment for serum LDL‐cholesterol levels. Conclusions No triglyceride‐derived metabolic parameter was predictive of any adverse outcome, either micro‐ or macrovascular events or mortality, suggesting that they should not be used for risk stratification in individuals with type 2 diabetes.
Cardoso et al. (Thu,) studied this question.
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