The effect of combination antibiotic therapy on mortality in patients with sepsis or septic shock due to Pseudomonas aeruginosa bloodstream infections: a systematic review

Key Points

• The aim is to evaluate the impact of combination antibiotic therapy on mortality rates in patients with sepsis or septic shock due to Pseudomonas aeruginosa.
• Conducted a systematic review of available literature on antibiotic therapy for sepsis.
• Analyzed outcomes related to mortality in patients receiving combination versus monotherapy.
• Focused on cases involving Pseudomonas aeruginosa bloodstream infections.
• Current evidence does not support the routine use of combination therapy over monotherapy.
• Combination therapy may be beneficial in select high-risk patients.
• Recommendations include prompt de-escalation of therapy once susceptibility data is available.