What question did this study set out to answer?

The aim is to investigate how HSV-1 infection affects microglial behavior and synapse maintenance in the brain.

February 23, 2026Cell Communication and Signaling0 citationsOpen Access

Herpes simplex virus-1 induces complement-mediated microglial phagocytosis of synapses in murine primary brain cultures and tissues

MMMariya Timotey MitevaIstituto di Farmacologia Traslazionale VPVirginia ProttoIstituto Superiore di Sanità FZFrancesco ZanziIstituto di Farmacologia Traslazionale

Key Points

The aim is to investigate how HSV-1 infection affects microglial behavior and synapse maintenance in the brain.
Utilized murine primary brain cultures and tissues
Induced HSV-1 infection
Analyzed complement activation and microglial response
HSV-1 infection led to increased complement activation
Complement-mediated microglial phagocytosis of damaged synapses was observed
Findings support a link between HSV-1 and neurodegeneration

Abstract

Our data indicate that HSV-1 infection triggers aberrant complement activation and complement-mediated microglial engulfment of damaged synapses, further supporting the role of HSV-1 in neurodegeneration.

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Cite This Study

Miteva et al. (Fri,) studied this question.

synapsesocial.com/papers/699bee1c1c6c6bad5397fdb9 https://doi.org/https://doi.org/10.1186/s12964-026-02745-y

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