Structural Tuning of Inefficient C 1 -Symmetric Iodoarene for Efficient Enantioselective Oxidative Organocatalysis

Key Points

• The research aims to develop an efficient iodoarene catalyst with C1 symmetry to enhance enantioselective oxidative transformations.
• Synthesis of a new C1 symmetric iodoarene catalyst
• Evaluation of catalytic performance in α-tosyloxylation of ketones
• Comparative studies with C2 symmetric analogs
• Density function theory studies to understand reaction mechanisms
• Achieved up to 85% yield and 75% enantioselectivity (ee) in catalytic reactions
• Demonstrated superior selectivity over C2 symmetric analogs, yielding racemic products
• Identified a key stereodetermining complex that supports enantioselectivity
• Verified broad substrate scope indicating versatility of the catalyst design