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February 25, 2026Environmental Science Advances0 citationsOpen Access

Metastatic Impact of Perfluorooctanoic Acid on Liver Cancer: Insights from HepG2 Cells and Zebrafish Xenograft Models

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KHKayla HawnEKEmma KenyonGBGregory Buck

Key Points

  • The aim is to investigate the role of perfluorooctanoic acid (PFOA) in liver cancer progression.
  • Utilized HepG2 cells to study cellular responses to PFOA exposure.
  • Implemented zebrafish xenograft models to assess tumor development and metastasis.
  • Conducted comparative analyses of cancer cell behavior under PFOA influence.
  • PFOA exposure increased metastatic traits in HepG2 cells.
  • Zebrafish models showed enhanced tumor growth with PFOA treatment.
  • Findings suggest a clear link between PFOA and liver cancer progression.

Abstract

Widely used in consumer products for their water- and grease-resistant properties, perfluorooctanoic acid (PFOA), a legacy per- and polyfluoroalkyl substance (PFAS), has been increasingly implicated in liver carcinogenesis. Long-term or...

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Cite This Study

Hawn et al. (2026) studied this question.

synapsesocial.com/papers/699e912ef5123be5ed04e8f7https://doi.org/10.1039/d5va00491h
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