Efficacy of nicotiflorin in ameliorating septic acute kidney injury: the role of PINK1/parkin in mitochondrial restoration and oxidative stress reduction. | Synapse
Efficacy of nicotiflorin in ameliorating septic acute kidney injury: the role of PINK1/parkin in mitochondrial restoration and oxidative stress reduction.
Evaluate the efficacy of nicotiflorin in treating septic acute kidney injury (AKI) through mitochondrial restoration.
Examined the effects of nicotiflorin on septic acute kidney injury
Analyzed mitochondrial function and oxidative stress levels
Investigated the role of the PINK1/Parkin pathway in treatment outcomes.
Nicotiflorin attenuated mitochondrial dysfunction in septic AKI.
Oxidative stress levels were significantly reduced by nicotiflorin treatment.
The PINK1/Parkin signaling pathway was implicated in the therapeutic effects.
Abstract
Conclusions: Nicotiflorin attenuates mitochondrial dysfunction and oxidative stress in septic AKI via PINK1/Parkin signaling pathway, suggesting its potential as a therapeutic agent for septic AKI.