A Molecular Engineering Platform for Enhanced Stokes Shift NIR-II Fluorophores Enabling High-Fidelity 1400 nm In Vivo Imaging

Key Points

• The aim is to develop a molecular engineering platform that enhances the Stokes shift of NIR-II fluorophores for better imaging.
• Developed novel fluorophores with enhanced Stokes shift for NIR-II imaging.
• Performed in vivo imaging to assess spatial resolution and penetration depth.
• Evaluated tissue scattering and autofluorescence effects on imaging quality.
• Achieved superior spatial resolution compared to previous NIR imaging methods.
• Demonstrated improved penetration depth in biological tissues.
• Showed reduced tissue scattering and autofluorescence, enhancing image clarity at 1400 nm.