Effect of site-specific lysine acetylation on tau binding to microtubules: mechanistic insights from all-atom molecular dynamics simulations

Key Points

• This research aims to understand how site-specific lysine acetylation influences tau's binding to microtubules.
• Conducted all-atom molecular dynamics simulations
• Analyzed the electrostatic interactions between tau and microtubules
• Assessed destabilization mechanisms of microtubules due to acetylation
• Identified significant changes in tau-microtubule binding caused by acetylation
• Revealed distinct molecular mechanisms underlying microtubule destabilization due to altered electrostatics
• Observed specific site preferences for acetylation affecting tau's structural stability