PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 26, 2026Biomaterials Science1 citations

Betulinic acid exacerbates biomolecular condensation of α-synuclein: Possible role in Parkinson's Disease

SBSoumojit BiswasKPKarthik PNMNimisha A Mavlankar

Key Points

  • The study investigates how betulinic acid affects aggregation of α-synuclein, which is linked to Parkinson's disease.
  • Assessment of α-synuclein biomolecular condensation
  • Analysis of amyloid structure formation
  • Comparison of conditions with and without betulinic acid
  • Betulinic acid significantly increases the formation of α-synuclein amyloid structures.
  • Findings suggest a correlation between betulinic acid exposure and progression of pathological features associated with Parkinson's disease.

Abstract

Aggregation of α-synuclein (α-SYN) into amyloid structures is closely linked to progression of Parkinson's disease (PD). Type 2 diabetes mellitus increases PD risk, sharing common pathological features like amyloid aggregation,...

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Biswas et al. (2026) studied this question.

synapsesocial.com/papers/699fe40c95ddcd3a253e83b8https://doi.org/10.1039/d5bm01817j
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives2024 · 31 citations
  2. 2Serine 129 Phosphorylation of α-Synuclein Induces Unfolded Protein Response-mediated Cell Death2008 · 149 citations
  3. 3Betulinic Acid, the first lupane-type triterpenoid isolated via bioactivity-guided fractionation, and identified by spectroscopic analysis from leaves of Nyctanthes arbor-tristis: its potential biological activities in vitro assays2018 · 36 citations
  4. 4Co‐administration of betulinic acid and methamphetamine causes toxicity to dopaminergic and serotonergic nerve terminals in the striatum of late adolescent rats2013 · 27 citations
  5. 5Liquid–Liquid Phase Separation in Disease2019 · 971 citations