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February 27, 20260 citations

Targeted nano delivery of p53 DNA and carvedilol for the treatment of dilated cardiomyopathy in a rat model.

NTNeha R. Tomar AVAruna Tara Vennela SMSatyajit Mukhopadhyay

Key Points

To evaluate the effectiveness of targeted nano delivery of p53 DNA and carvedilol for treating dilated cardiomyopathy.
Utilized targeted lipid-based nanoparticles for drug and gene delivery
Applied treatments in a rat model of dilated cardiomyopathy
Assessed biocompatibility and delivery efficiency of LANPs
Demonstrated improved myocardial delivery of p53 DNA and carvedilol
Resulted in significant therapeutic effects on cardiac function in the treated rats
Showed potential advantages over conventional delivery methods

Abstract

LANPs offer a promising, biocompatible platform for targeted myocardial delivery of gene and drug therapies and may serve as an effective strategy for treating cardiomyopathy.

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Tomar et al. (Wed,) studied this question.

synapsesocial.com/papers/69a1351ded1d949a99abea51 https://doi.org/https://doi.org/10.1080/17435889.2026.2634274

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