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February 27, 2026European Heart Journal12 citationsOpen Access

Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry

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LLL H L LundKarolinska InstitutetAMAldo P MaggioniAssociazione Nazionale Medici Cardiologi OspedalieriMCM. Crespo-LeiroUniversidade da Coruña

Key Result

In-hospital mortality in European HF patients was 5.1%, higher with lower EF; 1-year mortality ranged 3.9-22 per 100 patient-years, and 14-44% were rehospitalized for HF.

Key Points

  • The aim is to examine outcomes for heart failure patients based on ejection fraction levels.
  • Analyzed data from the ESC HF III registry
  • Monitored in-hospital mortality rates
  • Tracked event rates and rehospitalization over one year
  • In-hospital mortality was 5.1%, higher with lower ejection fraction
  • Event rates for death ranged from 3.9 to 22 per 100 patient-years
  • Rehospitalization for heart failure occurred in 14-44% of patients within a year, significantly higher after acute heart failure.

Structured PICO

P
Population
Patients with heart failure (reduced, mildly reduced, or preserved ejection fraction) in Europe and affiliated countries, including both hospitalized patients and out-patients.
O
Outcome
In-hospital mortality, and 1-year event rates for all-cause death, cardiovascular death, unknown cause of death, and heart failure (re-)hospitalization.hard clinical

This registry data highlights the substantial ongoing morbidity and mortality burden in heart failure across the ejection fraction spectrum, particularly following acute heart failure episodes.

Abstract

In HF in Europe and affiliated countries, in-hospital mortality was 5.1% and greater with lower ejection fraction. Among hospital survivors and out-patients over 1 year of follow-up, event rates per 100 patient-years varied for death, 3.9-22, CV death 1.7-13, and unknown cause of death 0.8-6.3. The percent of patients that were (re-)hospitalized for HF at least once over 1-year follow-up ranged 14-44% and was twice as high post-AHF compared with post-out-patient visit.

Expert Takes1 quote

“Patients with acute heart failure have approximately twice the risk of readmission and three times the risk of death compared to those treated as outpatients.”

Lars Lund, Professor of cardiology, Karolinska InstitutetKarolinska Institutetauto_pipelineNeutralView source
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Cite This Study

Lund et al. (2025) studied this question. In-hospital mortality in European HF patients was 5.1%, higher with lower EF; 1-year mortality ranged 3.9-22 per 100 patient-years, and 14-44% were rehospitalized for HF.

synapsesocial.com/papers/69a1351ded1d949a99abeb13https://doi.org/10.1093/eurheartj/ehaf1074
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