Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry

Figures

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  Figure 1. AHF: In-hospital mortality rates. Among patients enrolled with AHF (n = 3913, 39%), percent in-hospital mortality for HFrEF, HFmrEF, HFpEF. The overall in-hospital mortality was 5.1%. The duration of hospitalization (length of stay) was 9 (6–14) days overall, 8 (4–18) days in those who died during hospitalization, and 9 (6–13) days in those who were discharged alive

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  Figure 2. A: All-cause mortality in AHF vs out-patient HF (all EF categories combined). Patients lost to follow-up were excluded. In AHF, patients who died in hospital were excluded, and survival time is counted from time of hospital admission (baseline). Censoring occurred at last follow-up alive. The curves show cumulative incidence of all-cause death, unadjusted. The insert represents the same curves on a different scale. The inserted table shows percent 1-year mortality. Hazard ratios unadjusted include all patients not lost to follow up. Hazard ratios adjusted age and sex include age, sex and the age × sex interaction term. Hazard ratios fully adjusted are after adjustments for 14 covariates: age, sex, EF as continuous variable, previous hospitalization for HF, BMI, NYHA class (four levels), ischaemic aetiology yes/no, diabetes yes/no, systolic blood pressure, heart rate, number of symptoms (0–4 of rales, oedema, dyspnea at rest, orthopnea), haemoglobin, eGFR, natriuretic peptides; patients with missing data on any of these variables were excluded. A sensitivity analysis was performed adjusting for the same covariates except natriuretic peptides. 2B: All-cause mortality in HFrEF vs…

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  Figure 3. Event rates (95% CI) per 100 patient-years for numerous relevant outcomes in different combinations of EF category and AHF vs out-patient HF. Numbers are number of events per 100 patient-years of follow-up and ranges are 95% CIs. Patients with AHF who died during hospitalization and patients lost to follow-up are excluded. For patients with AHF who survived discharge, time is counted from day of admission (baseline). Figure 3A shows unadjusted event rates and Figure 3B shows event rates adjusted for age and sex

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  Figure 4. Number of HF hospitalizations and dispersion. Percentages are the percentage of patients who experienced 0, 1, 2, 3 or >3 hospitalizations for HF during a median follow up of 376 (360–432) days. Patients with AHF who died during the AHF hospitalization and patients lost to follow-up are excluded. For patients with AHF who survived to discharge, time is counted from day of admission (baseline) and number of hospitalizations exclude the baseline hospitalization